Journal of Clinical Oncology - Ekim 2010

ORIGINAL REPORTS

Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

Thomas Fischer,   Richard M. Stone,   Daniel J. DeAngelo,   Ilene Galinsky,   Elihu Estey,   Carlo Lanza,   Edward Fox,   Gerhard Ehninger,   Eric J. Feldman,   Gary J. Schiller,   Virginia M. Klimek,   Stephen D. Nimer,   D. Gary Gilliland,   Catherine Dutreix,   Alice Huntsman-Labed,   Jodi Virkus,   and Francis J. Giles   JCO Oct 1, 2010:4339-4345; published online on August 23, 2010;10.1200/JCO.2010.28.9678.  [Abstract
 
 
REVIEW ARTICLE
 
Tumor Antigen–Targeted, Monoclonal Antibody–Based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape
Robert L. Ferris,   Elizabeth M. Jaffee,   and Soldano Ferrone   JCO Oct 1, 2010:4390-4399; published online on August 9, 2010;10.1200/JCO.2009.27.6360.  [Abstract]  
 
 
ORIGINAL REPORTS
 
Adjuvant Gemcitabine Alone Versus Gemcitabine-Based Chemoradiotherapy After Curative Resection for Pancreatic Cancer: A Randomized EORTC-40013-22012/FFCD-9203/GERCOR Phase II Study
Jean-Luc Van Laethem,   Pascal Hammel,   Françoise Mornex,   David Azria,   Geertjan Van Tienhoven,   Philippe Vergauwe,   Marc Peeters,   Marc Polus,   Michel Praet,   Murielle Mauer,   Laurence Collette,   Volker Budach,   Manfred Lutz,   Eric Van Cutsem,   and Karin Haustermans   JCO Oct 10, 2010:4450-4456; published online on September 13, 2010;10.1200/JCO.2010.30.3446.  [Abstract
 
 
REVIEW ARTICLE
 
International Myeloma Working Group Consensus Statement Regarding the Current Status of Allogeneic Stem-Cell Transplantation for Multiple Myeloma
Henk Lokhorst,   Hermann Einsele,   David Vesole,   Benedetto Bruno,   Jesus San Miguel,   Jose A. Pérez-Simon,   Nicolaus Kröger,   Philippe Moreau,   Gosta Gahrton,   Cristina Gasparetto,   Sergio Giralt,   and William Bensinger   JCO Oct 10, 2010:4521-4530; published online on August 9, 2010;10.1200/JCO.2010.29.7929.  [Abstract]  
 
 
ORIGINAL REPORTS
 
Phase III Randomized Trial Assessing Rofecoxib in the Adjuvant Setting of Colorectal Cancer: Final Results of the VICTOR Trial
Rachel S. Midgley,   Christopher C. McConkey,   Elaine C. Johnstone,   Janet A. Dunn,   Justine L. Smith,   Simon A. Grumett,   Patrick Julier,   Claire Iveson,   Yoko Yanagisawa,   Bryan Warren,   Michael J. Langman,   and David J. Kerr   JCO Oct 20, 2010:4575-4580; published online on September 13, 2010;10.1200/JCO.2010.29.6244.  [Abstract]  
 
Results of the CONFIRM Phase III Trial Comparing Fulvestrant 250 mg With Fulvestrant 500 mg in Postmenopausal Women With Estrogen Receptor–Positive Advanced Breast Cancer
Angelo Di Leo,  Guy Jerusalem,  Lubos Petruzelka,  Roberto Torres,  Igor N. Bondarenko,  Rustem Khasanov,  Didier Verhoeven,  José L. Pedrini,  Iya Smirnova,  Mikhail R. Lichinitser,  Kelly Pendergrass,  Sally Garnett,  Justin P.O. Lindemann,  Francisco Sapunar,  and Miguel Martin JCO Oct 20, 2010:4594-4600; published online on September 20, 2010;10.1200/JCO.2010.28.8415. [Abstract]
 
Temozolomide Versus Procarbazine, Lomustine, and Vincristine in Recurrent High-Grade Glioma
Michael Brada,  Sally Stenning,  Rhian Gabe,  Lindsay C. Thompson,  David Levy,  Roy Rampling,  Sara Erridge,  Frank Saran,  Rao Gattamaneni,  Kirsten Hopkins,  Sarah Beall,  V. Peter Collins,  and Siow-Ming Lee JCO Oct 20, 2010:4601-4608; published online on September 20, 2010;10.1200/JCO.2009.27.1932. [Abstract
 
Phase II Study of Dasatinib in Patients With Advanced Non–Small-Cell Lung Cancer
Faye M. Johnson,  B. Nebiyou Bekele,  Lei Feng,  Ignacio Wistuba,  Xi Ming Tang,  Hai T. Tran,  Jeremy J. Erasmus,  Li-Ling Hwang,  Naoko Takebe,  George R. Blumenschein,  Scott M. Lippman,  and David J. Stewart JCO Oct 20, 2010:4609-4615; published online on September 20, 2010;10.1200/JCO.2010.30.5474. [Abstract]
 
Bortezomib Plus Dexamethasone Is Superior to Vincristine Plus Doxorubicin Plus Dexamethasone As Induction Treatment Prior to Autologous Stem-Cell Transplantation in Newly Diagnosed Multiple Myeloma: Results of the IFM 2005-01 Phase III Trial
Jean-Luc Harousseau,  Michel Attal,  Hervé Avet-Loiseau,  Gerald Marit,  Denis Caillot,  Mohamad Mohty,  Pascal Lenain,  Cyrille Hulin,  Thierry Facon,  Philippe Casassus,  Mauricette Michallet,  Hervé Maisonneuve,  Lotfi Benboubker,  Frédéric Maloisel,  Marie-Odile Petillon,  Iain Webb,  Claire Mathiot,  and Philippe Moreau JCO Oct 20, 2010:4621-4629; published online on September 7, 2010;10.1200/JCO.2009.27.9158. [Abstract]
 
Light Chain–Induced Acute Renal Failure Can Be Reversed by Bortezomib-Doxorubicin-Dexamethasone in Multiple Myeloma: Results of a Phase II Study
Heinz Ludwig,  Zdenek Adam,  Roman Hajek,  Richard Greil,  Elena Tóthová,  Felix Keil,  Eva Maria Autzinger,  Josef Thaler,  Heinz Gisslinger,  Alois Lang,  Miklós Egyed,  Irene Womastek,  and Niklas Zojer JCO Oct 20, 2010:4635-4641; published online on September 7, 2010;10.1200/JCO.2010.28.1238. [Abstract]
 
Prospective Evaluation of Allogeneic Hematopoietic Stem-Cell Transplantation From Matched Related and Matched Unrelated Donors in Younger Adults With High-Risk Acute Myeloid Leukemia: German-Austrian Trial AMLHD98A
Richard F. Schlenk,  Konstanze Döhner,  Silja Mack,  Michael Stoppel,  Franz Király,  Katharina Götze,  Frank Hartmann,  Heinz A. Horst,  Elisabeth Koller,  Andreas Petzer,  Wolfgang Grimminger,  Guido Kobbe,  Axel Glasmacher,  Hans Salwender,  Heinz Kirchen,  Detlef Haase,  Stephan Kremers,  Axel Matzdorff,  Axel Benner,  and Hartmut Döhner JCO Oct 20, 2010:4642-4648; published online on August 30, 2010;10.1200/JCO.2010.28.6856. [Abstract]
 
Randomized Phase II Window Trial of Two Schedules of Irinotecan With Vincristine in Patients With First Relapse or Progression of Rhabdomyosarcoma: A Report From the Children's Oncology Group
Leo Mascarenhas,  Elizabeth R. Lyden,  Philip P. Breitfeld,  David O. Walterhouse,  Sarah S. Donaldson,  Charles N. Paidas,  David M. Parham,  James R. Anderson,  William H. Meyer,  and Douglas S. Hawkins JCO Oct 20, 2010:4658-4663; published online on September 13, 2010;10.1200/JCO.2010.29.7390. [Abstract]